The MX Vertical Advanced Ergonomic Mouse from Logitech is their first attempt at offering a mouse which more aggressively reduces pronation than other mice in their line. The body of the MX Vertical is angled at a fixed 57° to reduce the risks associated with pronation of the forearm. The angled body is designed to provide the support necessary for the hand to "relax" while engaged with the mouse. However, those with smaller or narrower hands may find that they need to maintain a degree of tension to hold their hands "up" in position over the buttons. Large or wide hands will likely have less of a problem with this requirement to maintain hand position.

The MX Vertical is equipped with a top quality sensor capable of reading from 400 - 4000 DPI. Two nominal settings of 1000 and 1600 DPI can be adjusted anywhere within the range in 50 DPI increments. The top-mounted DPI button enables users to adjust the mouse as needed for basic or fine control movements. The scroll wheel has a rubber tire for grip and features distinct but soft detents. There are 4 programmable buttons (left, right, back, & forward).

The MX Vertical offers 3 connection options: Wired via the charging cord, 2.4Ghz Logitech Unifying Receiver with an operation distance up to 33 feet, and Bluetooth (Bluetooth Low Energy Technology required). The 270mAh Li-Po rechargeable battery can provide up to 4 months use on a single charge and offers a 1 minute Quick Charge that can provide up to 3 hours of use. Of course, individual usage may affect this. Using Logitech "FLOW" users are able to connect to and control up to 3 computing devices using a single mouse.

The "flatness" of the buttons on the MX Vertical prohibit the fingers from achieving a fully relaxed and naturally curved "position of function". This factor, combined with the almost slick surface on the buttons could lead users to try to "pinch" the mouse between the thumb and fingers in an attempt to achieve a better sensation of "control". In addition, to minimize the activation force on the buttons the fingertips need to be as close to the end of the buttons as possible. Those with large hands or very long fingers may be able to achieve this position but most users will find their fingertips falling short of this "optimum" position, resulting in a higher force being required for click activation.